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Are you an amateur python programmer??

An opportunity for contributing to cancer immunotherapy research is open !

No biology knowledge, No degree required, just being a die-hard python freak is sufficient !

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chimera idea

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Chimeric Antigen Receptor T cells (CAR-T cells) are truly revolutionary way of manipulating T cell signaling for therapeutic purposes. Till date CAR-T cell have been used to treat blood cancers (B-cell Non-Hodkgkin’s Lymphoma, B-cell lymphoblastic leukemia, refractory large B cell lymphoma) and cancers of the brain (glioblastoma & neuroblastoma). Several clinical trials are currently underway ...

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Can patient genetic make-up influence autoimmune adverse responses during immunotherapy?

Here is how we are addressing this question :-

Cancer-linked SNPs control T cell traits

#immunotherapy #cancer #germline #mutations #ProximalSignaling #variants #Tcell #phosphotyrosine
#signaling

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What we knew so far?
Using cell lines representative for the entire human population, we have learnt that membrane-bound signals are transmitted through the cytoplasm to the nucleus in the form of phosphate transfer reactions; a generalized signalling path dictated by membrane-bound tyrosine kinases and conveyed by the cytoplasmic effector molecules towards the nucleus (Ullrich ...

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There must be a molecular signalling link between immune evasion in tumor tissues and immunotherapy-induced organ-specific autoimmune adverse reactions (Michot et al. 2016; Abdel-Wahab, Shah, and Suarez-Almazor 2016).

While, on the one hand, the immune evasion (lack of T cell infiltration) in tumor tissues is a major concern for disease progression in cancer patients, on ...

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